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IFITM1 (基因名), Interferon-induced transmembrane protein 1 (蛋白名), ifm1_human.
产品名称:

Human IFITM1/ Interferon-induced transmembrane protein 1 Recombinant Protein
干扰素诱导跨膜蛋白1

货号:

R15511h

商标:
EIAab®
监管等级:
别名:

Dispanin subfamily A member 2a, Interferon-induced protein 17, Interferon-inducible protein 9-27, Leu-13 antigen, DSPA2a, CD225, CD225, IFI17

序列号:
P13164
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human IFITM1 Protein
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Human IFITM1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11p15.5 by HGNC 11p15.5 by Entrez Gene 11p15.5 by Ensembl
IFITM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Interacts with CD81.


功能:
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.


亚细胞位置:
Cell membrane Single-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth."

[2].
"TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen."

[3].
"The dispanins: a novel gene family of ancient origin that contains 14 human members."

[4].
"IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."

[5].
"IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells."

[6].
"Knockdown of interferon-induced transmembrane protein?1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells."

[7].
"The IFITM proteins inhibit HIV-1 infection."

[8].
"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus."

[9].
"ISG56 and IFITM1 proteins inhibit hepatitis C virus replication."

[10].
"Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus."
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