首页 > 重组蛋白 > Human IFITM3 Recombinant Protein

IFITM3 (基因名), Interferon-induced transmembrane protein 3 (蛋白名), ifm3_human.

产品名称:

Human IFITM3/ Interferon-induced transmembrane protein 3 Recombinant Protein
干扰素有道跨膜蛋白3

货号:

R10026h

商标:

EIAab^®

监管等级:

RUO

别名:

Dispanin subfamily A member 2b, Interferon-inducible protein 1-8U, DSPA2b

序列号:

Q01628

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human IFITM3 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 11p15.5 by HGNC 11p15.5 by Entrez Gene 11p15.5 by Ensembl

IFITM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with ATP6V0B and CD81 (By similarity). Interacts with SPP1; the interaction reduces OPN expression. Interacts with VAPA.

功能:

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

亚细胞位置:

Cell membrane Single-pass type II membrane protein Late endosome membrane Single-pass type II membrane protein Lysosome membrane Single-pass type II membrane protein

数据库链接

UniGene:

Hs.374650

STRING:

9606.ENSP00000382707

KEGG:

hsa:10410

MIM:

605579

Pfam:

PF04505

Uniprot:

Q01628

相关产品

Mouse Ifitm3 ELISA Kit

Rat ifitm3 ELISA Kit

Mouse Ifitm3 CLIA Kit

Rat ifitm3 CLIA Kit

Mouse Ifitm3 Protein

序列长度:

133

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

133:

STAKCLNIWA | LILGILMTIL | LIVIPVLIFQ | AYG

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Molecular analysis of a human interferon-inducible gene family."

(PMID: 1906403)

[2].

"Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis."

(PMID: 19946179)

[3].

"The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry."

(PMID: 23601107)

[4].

"The dispanins: a novel gene family of ancient origin that contains 14 human members."

(PMID: 22363774)

[5].

"IFITM3 restricts the morbidity and mortality associated with influenza."

(PMID: 22446628)

[6].

"IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."

(PMID: 22479637)

[7].

"S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus."

(PMID: 22511783)

[8].

"The IFITM proteins inhibit HIV-1 infection."

(PMID: 21177806)

[9].

"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus."

(PMID: 21253575)

[10].

"Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression."

(PMID: 19901966)

[1].

人干扰素有道跨膜蛋白3(IFITM3)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人干扰素有道跨膜蛋白3(IFITM3)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人干扰素有道跨膜蛋白3(IFITM3)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人干扰素有道跨膜蛋白3(IFITM3)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人干扰素有道跨膜蛋白3(IFITM3)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人干扰素有道跨膜蛋白3(IFITM3)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人干扰素有道跨膜蛋白3(IFITM3)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人干扰素有道跨膜蛋白3(IFITM3)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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