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KCNQ2 (基因名), Potassium voltage-gated channel subfamily KQT member 2 (蛋白名), kcnq2_human.
产品名称:

Human KCNQ2/ Potassium voltage-gated channel subfamily KQT member 2 Recombinant Protein
钾电压门控通道亚家族KQT成员2

货号:

R2348h

商标:
EIAab®
监管等级:
别名:

KQT-like 2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2, Voltage-gated potassium channel subunit Kv7.2

序列号:
O43526
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human KCNQ2 Protein
规格 & 价格: cart
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Human KCNQ2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 20q13.33 by HGNC 20q13.33 by Entrez Gene 20q13.33 by Ensembl
KCNQ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heteromultimer with KCNQ3. May associate with KCNE2.


功能:
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.


亚细胞位置:
Membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns."

[2].
"KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes."

[3].
"Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations."

[4].
"A novel mutation in KCNQ2 associated with BFNC, drug resistant epilepsy, and mental retardation."

[5].
"KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum."

[6].
"Suggestive evidence for association of two potassium channel genes with different idiopathic generalised epilepsy syndromes."

[7].
"Differential expression of kcnq2 splice variants: implications to m current function during neuronal development."

[8].
"Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel."

[9].
"Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy."

[10].
"Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy."
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