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KDM5D (基因名), Lysine-specific demethylase 5D (蛋白名), kdm5d_human.
产品名称:

Human KDM5D/ Lysine-specific demethylase 5D Recombinant Protein
Lysine-specific demethylase 5 d

货号:

R12893h

商标:
EIAab®
监管等级:
别名:

Histocompatibility Y antigen, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, H-Y, HY, HYA, JARID1D, KIAA0234, SMCY

序列号:
Q9BY66
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human KDM5D Protein
规格 & 价格: cart
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Human KDM5D Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: Yq11.223 by HGNC Yq11.223 by Entrez Gene Yq11.223 by Ensembl
KDM5D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with PCGF6, MSH5, ZMYND8, AR.


功能:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Gene sequence and evolutionary conservation of human SMCY."

[2].
"JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis."

[3].
"Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression."

[4].
"Spermatogenesis-specific association of SMCY and MSH5."

[5].
"The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases."

[6].
"Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein."

[7].
"Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission."

[8].
"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes."

[9].
"Population genetic implications from sequence variation in four Y chromosome genes."

[10].
"The serologically detected H-Y antigen revisited."
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