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KIRREL3 (基因名), Kin of IRRE-like protein 3 (蛋白名), kirr3_human.
产品名称:

Human KIRREL3/ Kin of IRRE-like protein 3 Recombinant Protein

货号:

R4427h

商标:
EIAab®
监管等级:
别名:

Kin of irregular chiasm-like protein 3, Nephrin-like protein 2, UNQ5923/PRO4502/PRO19814, KIAA1867, NEPH2

序列号:
Q8IZU9
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human KIRREL3 Protein
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Human KIRREL3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q24.2 by HGNC 11q24.2 by Entrez Gene 11q24.2 by Ensembl
KIRREL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer; mediates homophilic interactions to promote cell adhesion. Interacts with NPHS1; forms heterodimers with NPHS1 (By similarity). Interacts with NPHS2/podocin (via the C-terminus) (PubMed:12424224). Interacts with CASK (PubMed:19012874). Interacts (via extracellular region) with MAP1B (PubMed:25902260). Interacts (via extracellular region) with MYO16 (PubMed:25902260). Interacts (via intracellular region) with ATP1B1 (PubMed:25902260). Interacts (via intracellular region) with SHMT2 (PubMed:25902260). Interacts (via intracellular region) with UFC1 (PubMed:25902260).


功能:
Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.


亚细胞位置:
Processed kin of IRRE-like protein 3 Secreted


该产品尚未在任何出版物中被引用。

[1].
"NEPH1 defines a novel family of podocin interacting proteins."

[2].
"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."

[3].
"Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment."

[4].
"Identification of novel Kirrel3 gene splice variants in adult human skeletal muscle."

[5].
"Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs."
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