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LAG3 (基因名), Lymphocyte activation gene 3 protein (蛋白名), lag3_human.
产品名称:

Human LAG3/ Lymphocyte activation gene 3 protein Recombinant Protein
淋巴细胞激活基因3

货号:

R0914h

商标:
EIAab®
监管等级:
别名:

CD223, LAG-3, FDC

序列号:
P18627
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human LAG3 Protein
规格 & 价格: cart
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Human LAG3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12p13.31 by HGNC 12p13.31 by Entrez Gene 12p13.31 by Ensembl
LAG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MHC class II (MHC-II); selectively recognizes stable complexes of peptide and MHC-II (PubMed:1692078, PubMed:7589152, PubMed:8647185, PubMed:9159144). Interacts with FGL1 (via the Fibrinogen C-terminal domain) (PubMed:30580966).


功能:
Secreted lymphocyte activation gene 3 protein: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.


亚细胞位置:
Secreted lymphocyte activation gene 3 protein Secreted Produced following cleavage of the main chain.


该产品尚未在任何出版物中被引用。

[1].
"Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens."

[2].
"LAG-3, a novel lymphocyte activation gene closely related to CD4."

[3].
"High expression of lymphocyte-activation gene 3 (LAG3) in chronic lymphocytic leukemia cells is associated with unmutated immunoglobulin variable heavy chain region (IGHV) gene and reduced treatment-free survival."

[4].
"Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer."

[5].
"LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites."

[6].
"Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus."

[7].
"Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity."

[8].
"Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation."

[9].
"Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases."

[10].
"Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations."
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