首页 > 重组蛋白 > Human LAMB1 Recombinant Protein

LAMB1 (基因名), Laminin subunit beta-1 (蛋白名), lamb1_human.

产品名称:

Human LAMB1/ Laminin subunit beta-1 Recombinant Protein
层粘连蛋白β1亚基

货号:

R8728h

商标:

EIAab^®

监管等级:

RUO

别名:

Laminin B1 chain, Laminin-1 subunit beta, Laminin-10 subunit beta, Laminin-12 subunit beta, Laminin-2 subunit beta, Laminin-6 subunit beta, Laminin-8 subunit beta

序列号:

P07942

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human LAMB1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 7q31.1 by HGNC 7q31.1 by Entrez Gene 7q31.1 by Ensembl

LAMB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-6 (laminin-311 or K-laminin), laminin-8 (laminin-411), laminin-10 (laminin-511) and laminin-12 (laminin-213).

功能:

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.

亚细胞位置:

Secreted Extracellular space Extracellular matrix Basement membrane Major component.

数据库链接

UniGene:

Hs.650585

SMR:

P07942

STRING:

9606.ENSP00000222399

KEGG:

hsa:3912

MIM:

150240

Pfam:

PF00053

Uniprot:

P07942

相关产品

Mouse Lamb1 ELISA Kit

Chicken LAMB1 ELISA Kit

Mouse Lamb1 CLIA Kit

Chicken LAMB1 CLIA Kit

Mouse Lamb1 Protein

序列长度:

1786

序列:

仅供参考，详细请咨询（services@eiaab.com）

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1786:

QRYLEDKAQE | LARLEGEVRS | LLKDISQKVA | VYSTCL

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities."

(PMID: 23472759)

[2].

"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

(PMID: 20201926)

[3].

"Genome-wide association identifies multiple ulcerative colitis susceptibility loci."

(PMID: 20228799)

[4].

"A common variant in DRD3 receptor is associated with autism spectrum disorder."

(PMID: 19058789)

[5].

"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging."

(PMID: 19834535)

[6].

"Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region."

(PMID: 19915572)

[7].

"Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study."

(PMID: 19122664)

[8].

"Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression."

(PMID: 18162078)

[9].

"Genes associated with the genesis of leiomyoma of the uterus in a commonly deleted chromosomal region at 7q22."

(PMID: 15706419)

[10].

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."

(PMID: 16335952)

[1].

人层粘连蛋白β1亚基(LAMB1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人层粘连蛋白β1亚基(LAMB1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人层粘连蛋白β1亚基(LAMB1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人层粘连蛋白β1亚基(LAMB1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人层粘连蛋白β1亚基(LAMB1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人层粘连蛋白β1亚基(LAMB1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人层粘连蛋白β1亚基(LAMB1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人层粘连蛋白β1亚基(LAMB1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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