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LAMP2 (基因名), Lysosome-associated membrane glycoprotein 2 (蛋白名), lamp2_human.
产品名称:

Human LAMP2/ Lysosome-associated membrane glycoprotein 2 Recombinant Protein
溶酶体相关膜糖蛋白2

货号:

R1464h

商标:
EIAab®
监管等级:
别名:

CD107 antigen-like family member B, LGP-96, CD107b, LAMP-2

序列号:
P13473
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human LAMP2 Protein
规格 & 价格: cart
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Human LAMP2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: Xq24 by HGNC Xq24 by Entrez Gene Xq24 by Ensembl
LAMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer (PubMed:18644871, PubMed:25342746). Homodimer (PubMed:25342746). Homotrimer (PubMed:25342746). Forms large homooligomers (PubMed:18644871). Interacts (via its cytoplasmic region) with HSPA8 (PubMed:25342746). Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity). Interacts with MLLT11 (PubMed:24880125).


功能:
Isoform LAMP-2C: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Endosome membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Cytoplasmic vesicle Autophagosome membrane This protein shuttles between lysosomes, endosomes, and the plasma membrane.


该产品尚未在任何出版物中被引用。

[1].
"Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene."

[2].
"Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2."

[3].
"Glycogen storage diseases presenting as hypertrophic cardiomyopathy."

[4].
"The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones."

[5].
"LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes."

[6].
"LAMP-2C Inhibits MHC Class II Presentation of Cytoplasmic Antigens by Disrupting Chaperone-Mediated Autophagy."

[7].
"Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP-2A) reveals key features for substrate specificity in chaperone-mediated autophagy."

[8].
"Degradation of AF1Q by chaperone-mediated autophagy."

[9].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[10].
"LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens."
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