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LANCL2 (基因名), LanC-like protein 2 (蛋白名), lanc2_human.
产品名称:

Human LANCL2/ LanC-like protein 2 Recombinant Protein

货号:

R2848h

商标:
EIAab®
监管等级:
别名:

Testis-specific adriamycin sensitivity protein, GPR69B, TASP

序列号:
Q9NS86
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human LANCL2 Protein
规格 & 价格: cart
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Human LANCL2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 7p11.2 by HGNC 7p11.2 by Entrez Gene 7p11.2 by Ensembl
LANCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.


功能:
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.


亚细胞位置:
Nucleus Cytoplasm Cell membrane Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580).


该产品尚未在任何出版物中被引用。

[1].
"LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells."

[2].
"Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin."

[3].
"Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism."

[4].
"Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Human chromosome 7: DNA sequence and biology."

[8].
"The DNA sequence of human chromosome 7."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors."
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