首页 > 重组蛋白 > Human LBP Recombinant Protein

LBP (基因名), Lipopolysaccharide-binding protein (蛋白名), lbp_human.

产品名称:

Human LBP/ Lipopolysaccharide-binding protein Recombinant Protein
脂多糖结合蛋白

货号:

R1406h

商标:

EIAab^®

监管等级:

RUO

别名:

LBP

序列号:

P18428

来源:

E.coli

种属:

Human

标签:

His

序列:

122-233aa

预估分子量:

12.32 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Immunology

规格 & 价格:

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Human LBP Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The PCR product of human LBP gene was determined by 1% Agarose stained with EB.

Recombinant human LBP protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 20q11.23 by HGNC 20q11.23 by Entrez Gene 20q11.23 by Ensembl

LBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

功能:

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

亚细胞位置:

Secreted Cytoplasmic granule membrane Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

数据库链接

UniGene:

Hs.154078

SMR:

P18428

STRING:

9606.ENSP00000217407

KEGG:

hsa:3929

MIM:

151990

Pfam:

PF01273

Uniprot:

P18428

相关产品

序列长度:

481

序列:

仅供参考，详细请咨询（services@eiaab.com）

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481:

PLLKRVQLYD | LGLQIHKDFL | FLGANVQYMR | V

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Lipopolysaccharide-binding protein (LBP) gene polymorphisms: rapid genotyping by real-time PCR and association with infective endocarditis."

(PMID: 19560454)

[2].

"A common haplotype of the LBP gene predisposes to severe sepsis."

(PMID: 19707138)

[3].

"Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation."

(PMID: 18056482)

[4].

"Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction."

(PMID: 12521224)

[5].

"Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis."

(PMID: 11373419)

[6].

"The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved."

(PMID: 9240454)

[7].

"Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins."

(PMID: 9441745)

[8].

"Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation."

(PMID: 7517398)

[9].

"The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity."

(PMID: 24120359)

[10].

"Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease."

(PMID: 20346360)

[1].

人脂多糖结合蛋白(LBP)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人脂多糖结合蛋白(LBP)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人脂多糖结合蛋白(LBP)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人脂多糖结合蛋白(LBP)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人脂多糖结合蛋白(LBP)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人脂多糖结合蛋白(LBP)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人脂多糖结合蛋白(LBP)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人脂多糖结合蛋白(LBP)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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