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LCP2 (基因名), Lymphocyte cytosolic protein 2 (蛋白名), lcp2_human.
产品名称:

Human LCP2/ Lymphocyte cytosolic protein 2 Recombinant Protein
淋巴细胞胞浆蛋白2

货号:

R9113h

商标:
EIAab®
监管等级:
别名:

SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76

序列号:
Q13094
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human LCP2 Protein
规格 & 价格: cart
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Human LCP2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 5q35.1 by HGNC 5q35.1 by Entrez Gene 5q35.1 by Ensembl
LCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with SLA. Interacts with CBLB (By similarity). Interacts with GRB2 (PubMed:7706237). Interacts with SHB (PubMed:12084069). Interacts with PRAM1 (PubMed:11301322). Interacts (via SH2 domain) with CD6 (via tyrosine phosphorylated C-terminus) (PubMed:16914752, PubMed:24584089). Interacts with FYB and the phosphorylated form of ARAP (PubMed:27335501).


功能:
Involved in T-cell antigen receptor mediated signaling.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76."

[2].
"Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase."

[3].
"Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells."

[4].
"ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion."

[5].
"Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub."

[6].
"Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells."

[7].
"The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells."

[8].
"c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest."

[9].
"Candidate gene analysis in primary lymphedema."

[10].
"T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76."
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