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LDLR (基因名), Low-density lipoprotein receptor (蛋白名), ldlr_human.
产品名称:

Human LDLR/ Low-density lipoprotein receptor Recombinant Protein
低密度脂蛋白受体

货号:

R1008h

商标:
EIAab®
监管等级:
别名:

LDL receptor

序列号:
P01130
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human LDLR Protein
规格 & 价格: cart
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Human LDLR Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19p13.2 by HGNC 19p13.2 by Entrez Gene 19p13.2 by Ensembl
LDLR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
(Microbial infection) May interact with HIV-1 Tat.


功能:
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins (PubMed:10535997, PubMed:12615904). Acts as a receptor for vesicular stomatitis virus (PubMed:23589850). In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells (PubMed:11100124).


亚细胞位置:
Cell membrane Single-pass type I membrane protein Membrane Clathrin-coated pit Golgi apparatus Early endosome Late endosome Lysosome Rapidly endocytosed upon ligand binding.



[1].
"Molecular characterization of Polish patients with familial hypercholesterolemia: novel and recurrent LDLR mutations."

[2].
"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip."

[3].
"The molecular basis of familial hypercholesterolemia in Lebanon: spectrum of LDLR mutations and role of PCSK9 as a modifier gene."

[4].
"Genetic diagnosis of familial hypercholesterolemia using a DNA-array based platform."

[5].
"Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia."

[6].
"The effect of atorvastatin treatment on lipid profile and adhesion molecule levels in hypercholesterolemic patients: relation to low-density lipoprotein receptor gene polymorphism."

[7].
"Analysis of polymorphisms in the 3' untranslated region of the LDL receptor gene and their effect on plasma cholesterol levels and drug response."

[8].
"Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER."

[9].
"Frequency of low-density lipoprotein receptor gene mutations in patients with a clinical diagnosis of familial combined hyperlipidemia in a clinical setting."

[10].
"The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR."
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