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LGMN (基因名), Legumain (蛋白名), lgmn_human.
产品名称:

Human LGMN/ Legumain Recombinant Protein
Legumain

货号:

R1201h

商标:
EIAab®
监管等级:
别名:

Asparaginyl endopeptidase, Protease, cysteine 1, PRSC1

序列号:
Q99538
来源:
E.coli
种属:
Human
标签:
His
序列:
18-323aa
预估分子量:
33.66 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human LGMN Protein
规格 & 价格: cart
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Human LGMN Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 14q32.12 by HGNC 14q32.12 by Entrez Gene 14q32.12 by Ensembl
LGMN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer before autocatalytic removal of the propeptide (By similarity). Monomer after autocatalytic processing. May interact with integrins.


功能:
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.


亚细胞位置:
Lysosome


该产品尚未在任何出版物中被引用。

[1].
"Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase."

[2].
"Activation of human prolegumain by cleavage at a C-terminal asparagine residue."

[3].
"Autocatalytic activation of human legumain at aspartic acid residues."

[4].
"Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1."

[5].
"Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation."
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