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LMAN1 (基因名), Protein ERGIC-53 (蛋白名), lman1_human.
产品名称:

Human LMAN1/ Protein ERGIC-53 Recombinant Protein
ERGIC-53蛋白

货号:

R9737h

商标:
EIAab®
监管等级:
别名:

ER-Golgi intermediate compartment 53 kDa protein, Gp58, Intracellular mannose-specific lectin MR60, Lectin mannose-binding 1, ERGIC53, F5F8D

序列号:
P49257
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human LMAN1 Protein
规格 & 价格: cart
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Human LMAN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 18q21.32 by HGNC 18q21.32 by Entrez Gene 18q21.32 by Ensembl
LMAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2. May interact with TMEM115.


功能:
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.


亚细胞位置:
Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII."

[2].
"A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia."

[3].
"ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families."

[4].
"Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII."

[5].
"ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells."

[6].
"ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif."

[7].
"TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport."

[8].
"Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking."

[9].
"Risk of meningioma and common variation in genes related to innate immunity."

[10].
"Polymorphisms in innate immunity genes and risk of childhood leukemia."
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