首页 > 重组蛋白 > Human LRPPRC Recombinant Protein

LRPPRC (基因名), Leucine-rich PPR motif-containing protein, mitochondrial (蛋白名), lpprc_human.

产品名称:

Human LRPPRC/ Leucine-rich PPR motif-containing protein, mitochondrial Recombinant Protein
线粒体富亮氨酸PPR膜体蛋白

货号:

R14393h

商标:

EIAab^®

监管等级:

RUO

别名:

130 kDa leucine-rich protein, GP130, LRP 130, LRP130

序列号:

P42704

来源:

E.coli

种属:

Human

标签:

His

序列:

1121-1351aa

预估分子量:

25.41 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The PCR product of human LRPPRC gene was determined by 1% Agarose stained with EB.

Recombinant human LRPPRC protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 2p21 by HGNC 2p21 by Entrez Gene 2p21 by Ensembl

LRPPRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with CECR2, HEBP2, MAP1S and UXT. Interacts with PPARGC1A. Interacts with FOXO1 (By similarity). Component of mRNP complexes associated with HNRPA1.

功能:

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA.

亚细胞位置:

Mitochondrion Nucleus Nucleoplasm Nucleus inner membrane Nucleus outer membrane Seems to be predominantly mitochondrial.

数据库链接

UniGene:

Hs.368084

STRING:

9606.ENSP00000260665

KEGG:

hsa:10128

MIM:

220111

Pfam:

PF01535

Uniprot:

P42704

相关产品

Mouse Lrpprc ELISA Kit

Rat Lrpprc ELISA Kit

Mouse Lrpprc CLIA Kit

Rat Lrpprc CLIA Kit

Mouse Lrpprc Protein

序列长度:

1394

序列:

仅供参考，详细请咨询（services@eiaab.com）

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1394:

LDDLFLKRYA | SLLKYAGEPV | PFIEPPESFE | FYAQQLRKLR | ENSS

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Molecular cloning and expression of the gene for a major leucine-rich protein from human hepatoblastoma cells (HepG2)."

(PMID: 8012652)

[2].

"Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics."

(PMID: 12529507)

[3].

"LRP130, a pentatricopeptide motif protein with a noncanonical RNA-binding domain, is bound in vivo to mitochondrial and nuclear RNAs."

(PMID: 12832482)

[4].

"LRPPRC mutations cause early-onset multisystem mitochondrial disease outside of the French-Canadian population."

(PMID: 26510951)

[5].

"LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs."

(PMID: 22045337)

[6].

"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

(PMID: 20201926)

[7].

"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

(PMID: 20877624)

[8].

"Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex."

(PMID: 17050673)

[9].

"Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein."

(PMID: 15907802)

[10].

"New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP130 protein."

(PMID: 15272088)

[1].

人线粒体富亮氨酸PPR膜体蛋白(LRPPRC)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人线粒体富亮氨酸PPR膜体蛋白(LRPPRC)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人线粒体富亮氨酸PPR膜体蛋白(LRPPRC)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人线粒体富亮氨酸PPR膜体蛋白(LRPPRC)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人线粒体富亮氨酸PPR膜体蛋白(LRPPRC)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人线粒体富亮氨酸PPR膜体蛋白(LRPPRC)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人线粒体富亮氨酸PPR膜体蛋白(LRPPRC)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人线粒体富亮氨酸PPR膜体蛋白(LRPPRC)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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