首页 > 重组蛋白 > Human LRP8 Recombinant Protein

LRP8 (基因名), Low-density lipoprotein receptor-related protein 8 (蛋白名), lrp8_human.

产品名称:

Human LRP8/ Low-density lipoprotein receptor-related protein 8 Recombinant Protein
低密度脂蛋白受体相关蛋白8

货号:

R10006h

商标:

EIAab^®

监管等级:

RUO

别名:

Apolipoprotein E receptor 2, LRP-8, APOER2

序列号:

Q14114

来源:

E.coli

种属:

Human

标签:

His

序列:

52-153aa

预估分子量:

11.22 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cardiovascular

规格 & 价格:

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产品说明书

说明书:

MSDS:

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数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The sequence analysis of human LRP8 protein including hydrophilcity, hydrophobicity and antigenicity.

Recombinant human LRP8 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 1p32.3 by HGNC 1p32.3 by Entrez Gene 1p32.3 by Ensembl

LRP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Reelin associates with two or more receptor molecules. Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17 (By similarity). Interacts with PCSK9.

功能:

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

亚细胞位置:

Cell membrane Single-pass type I membrane protein Secreted Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.

数据库链接

UniGene:

Hs.280387

SMR:

Q14114

STRING:

9606.ENSP00000303634

KEGG:

hsa:7804

MIM:

602600

Pfam:

PF00057

Uniprot:

Q14114

相关产品

Mouse Lrp8 ELISA Kit

Chicken LRP8 ELISA Kit

Mouse Lrp8 CLIA Kit

Chicken LRP8 CLIA Kit

Mouse Lrp8 Protein

序列长度:

963

序列:

仅供参考，详细请咨询（services@eiaab.com）

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963:

KRVALSLEDD | GLP

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease."

(PMID: 12399018)

[2].

"Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene."

(PMID: 9079678)

[3].

"Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain."

(PMID: 8626535)

[4].

"Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia."

(PMID: 17614163)

[5].

"Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study."

(PMID: 19439088)

[6].

"The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."

(PMID: 18039658)

[7].

"An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction."

(PMID: 17847002)

[8].

"Differential binding of ligands to the apolipoprotein E receptor 2."

(PMID: 12899622)

[9].

"Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain."

(PMID: 12950167)

[10].

"Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells."

(PMID: 12681505)

[1].

人低密度脂蛋白受体相关蛋白8(LRP8)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人低密度脂蛋白受体相关蛋白8(LRP8)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人低密度脂蛋白受体相关蛋白8(LRP8)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人低密度脂蛋白受体相关蛋白8(LRP8)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人低密度脂蛋白受体相关蛋白8(LRP8)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人低密度脂蛋白受体相关蛋白8(LRP8)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人低密度脂蛋白受体相关蛋白8(LRP8)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人低密度脂蛋白受体相关蛋白8(LRP8)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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