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EEF1E1 (基因名), Eukaryotic translation elongation factor 1 epsilon-1 (蛋白名), mca3_human.
产品名称:

Human EEF1E1/ Eukaryotic translation elongation factor 1 epsilon-1 Recombinant Protein

货号:

R11479h

商标:
EIAab®
监管等级:
别名:

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3, Elongation factor p18, Multisynthase complex auxiliary component p18, AIMP3, P18

序列号:
O43324
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human EEF1E1 Protein
规格 & 价格: cart
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Human EEF1E1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 6p24.3 by HGNC 6p24.3 by Entrez Gene 6p24.3 by Ensembl
EEF1E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation.


功能:
Positive modulator of ATM response to DNA damage.


亚细胞位置:
Cytoplasm Nucleus Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.


该产品尚未在任何出版物中被引用。

[1].
"Dissection of the structural organization of the aminoacyl-tRNA synthetase complex."

[2].
"The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR."

[3].
"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."

[4].
"Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains."

[5].
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

[6].
"Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells."

[7].
"Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers."

[8].
"Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"The DNA sequence and analysis of human chromosome 6."
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