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NOG (基因名), Noggin (蛋白名), nogg_human.
产品名称:

Human NOG/ Noggin Recombinant Protein
头蛋白

货号:

R0796h

商标:
EIAab®
监管等级:
序列号:
Q13253
来源:
E.coli
种属:
Human
标签:
His
序列:
28-232aa
预估分子量:
22.55 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Development Biology
  • Human NOG Protein
  • Human NOG Protein
  • Human NOG Protein
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Human NOG Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human NOG Protein
The PCR product of human NOG gene was determined by 1% Agarose stained with EB.
Human NOG Protein
Recombinant human NOG protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 17q22 by HGNC 17q22 by Entrez Gene 17q22 by Ensembl
NOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation.


功能:
Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732).


亚细胞位置:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism."

[2].
"Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis."

[3].
"Identification of mammalian noggin and its expression in the adult nervous system."

[4].
"Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation."

[5].
"Identification and association analysis of single nucleotide polymorphisms in the human noggin (NOG) gene and osteoporosis phenotypes."

[6].
"Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism."

[7].
"Structural basis of BMP signalling inhibition by the cystine knot protein Noggin."

[8].
"Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome."

[9].
"A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal."

[10].
"A GDF5 point mutation strikes twice--causing BDA1 and SYNS2."
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