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OCLN (基因名), Occludin (蛋白名), ocln_human.
产品名称:

Human OCLN/ Occludin Recombinant Protein
闭合蛋白

货号:

R14928h

商标:
EIAab®
监管等级:
序列号:
Q16625
来源:
E.coli
种属:
Human
标签:
His
序列:
269-522aa
预估分子量:
27.94 kDa (monomer)
纯度:
Greater than 98% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
  • Human OCLN Protein
  • Human OCLN Protein
  • Human OCLN Protein
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Human OCLN Protein
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human OCLN Protein
The PCR product of human OCLN gene was determined by 1% Agarose stained with EB.
Human OCLN Protein
Recombinant human OCLN protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 5q13.2 by HGNC 5q13.2 by Entrez Gene 5q13.2 by Ensembl
OCLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with TJP1/ZO1 and with VAPA.


功能:
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.


亚细胞位置:
Cell membrane Multi-pass membrane protein Cell junction Tight junction


该产品尚未在任何出版物中被引用。

[1].
"Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues."

[2].
"Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria."

[3].
"Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry."

[4].
"Claudin association with CD81 defines hepatitis C virus entry."

[5].
"Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells."

[6].
"Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approach."

[7].
"PKC eta regulates occludin phosphorylation and epithelial tight junction integrity."

[8].
"Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions."

[9].
"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."

[10].
"Human protein factory for converting the transcriptome into an in vitro-expressed proteome,."
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