首页 > 重组蛋白 > Human PDE9A Recombinant Protein

PDE9A (基因名), High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (蛋白名), pde9a_human.

产品名称:

Human PDE9A/ High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Recombinant Protein
高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A

货号:

R12007h

商标:

EIAab^®

监管等级:

RUO

序列号:

O76083

来源:

E.coli

种属:

Human

标签:

His

序列:

Recombinant protein

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human PDE9A Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 21q22.3 by HGNC 21q22.3 by Entrez Gene 21q22.3 by Ensembl

PDE9A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer.

功能:

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory.

亚细胞位置:

Isoform PDE9A17 Cytoplasm Endoplasmic reticulum

数据库链接

UniGene:

Hs.473927

SMR:

O76083

STRING:

9606.ENSP00000291539

KEGG:

hsa:5152

MIM:

602973

Pfam:

PF00233

Uniprot:

O76083

相关产品

Mouse Pde9a ELISA Kit

Mouse Pde9a CLIA Kit

Mouse Pde9a Protein

Mouse Pde9a Polyclonal Antibody

Mouse Pde9a Monoclonal Antibody

序列长度:

593

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

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500:

550:

593:

EELKRIDDAM | KELQKKTDSL | TSGATEKSRE | RSRDVKNSEG | DCA

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase."

(PMID: 9624146)

[2].

"Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response."

(PMID: 17008408)

[3].

"Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene."

(PMID: 17090334)

[4].

"Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants."

(PMID: 14527714)

[5].

"Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence."

(PMID: 9856478)

[6].

"Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease."

(PMID: 25799991)

[7].

"Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo."

(PMID: 22328573)

[8].

"Genome-wide association study of lung function decline in adults with and without asthma."

(PMID: 22424883)

[9].

"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

(PMID: 20379614)

[10].

"Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis."

(PMID: 20121115)

[1].

人高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A(PDE9A)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A(PDE9A)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A(PDE9A)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A(PDE9A)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A(PDE9A)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A(PDE9A)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A(PDE9A)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A(PDE9A)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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Human PDE9A/ High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Recombinant Protein高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A

R12007h

Human PDE9A/ High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Recombinant Protein
高亲和力cGMP特异性3’，5’-环磷酸二酯酶9A