首页 > 重组蛋白 > Human PDGFA Recombinant Protein

PDGFA (基因名), Platelet-derived growth factor subunit A (蛋白名), pdgfa_human.

产品名称:

Human PDGFA/ Platelet-derived growth factor subunit A Recombinant Protein
血小板源生长因子亚基A

货号:

R0112h

商标:

EIAab^®

监管等级:

RUO

别名:

PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide, PDGF subunit A, PDGF1

序列号:

P04085

来源:

E.coli

种属:

Human

标签:

His

序列:

87-211aa

预估分子量:

13.75 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human PDGFA protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 7p22.3 by HGNC 7p22.3 by Entrez Gene 7p22.3 by Ensembl

PDGFA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.

功能:

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.

亚细胞位置:

Secreted Released by platelets upon wounding.

数据库链接

UniGene:

Hs.535898

SMR:

P04085

STRING:

9606.ENSP00000346508

KEGG:

hsa:5154

MIM:

173430

Pfam:

PF00341

Uniprot:

P04085

相关产品

Mouse Pdgfa ELISA Kit

Rat Pdgfa ELISA Kit

Bovine PDGFA ELISA Kit

Mouse Pdgfa CLIA Kit

Rat Pdgfa CLIA Kit

序列长度:

211

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

211:

KKRKRKRLKP | T

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"DNA sequence variants of the platelet-derived growth factor A-chain gene."

(PMID: 11678848)

[2].

"The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22."

(PMID: 1505216)

[3].

"Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite."

(PMID: 1612586)

[4].

"Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population."

(PMID: 20485444)

[5].

"Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex."

(PMID: 20534510)

[6].

"Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas."

(PMID: 19707201)

[7].

"Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries."

(PMID: 18326546)

[8].

"High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF."

(PMID: 18592007)

[9].

"Expression of epidermal growth factor, fibroblast growth factor-2, and platelet-derived growth factor-A in the eutopic endometrium of women with endometriosis."

(PMID: 17578349)

[10].

"Retinoic acid inducibility of the human PDGF-a gene is mediated by 5'-distal DNA motifs that overlap with basal enhancer and vitamin D response elements."

(PMID: 17933214)

[1].

人血小板源生长因子亚基A(PDGFA)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人血小板源生长因子亚基A(PDGFA)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人血小板源生长因子亚基A(PDGFA)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人血小板源生长因子亚基A(PDGFA)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人血小板源生长因子亚基A(PDGFA)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人血小板源生长因子亚基A(PDGFA)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人血小板源生长因子亚基A(PDGFA)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人血小板源生长因子亚基A(PDGFA)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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