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PEX5 (基因名), Peroxisomal targeting signal 1 receptor (蛋白名), pex5_human.
产品名称:

Human PEX5/ Peroxisomal targeting signal 1 receptor Recombinant Protein
过氧化物酶体靶向信号1受体

货号:

R12068h

商标:
EIAab®
监管等级:
别名:

PTS1-BP, Peroxin-5, Peroxisomal C-terminal targeting signal import receptor, Peroxisome receptor 1, PTS1 receptor, PXR1

序列号:
P50542
来源:
E.coli
种属:
Human
标签:
His
序列:
139-339aa
预估分子量:
22.11 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human PEX5 Protein
规格 & 价格: cart
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Human PEX5 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human PEX5 Protein
Recombinant human PEX5 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 12p13.31 by HGNC 12p13.31 by Entrez Gene 12p13.31 by Ensembl
PEX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with PEX7 and PEX13 (By similarity). Interacts with PEX12 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6.


功能:
Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.


亚细胞位置:
Cytoplasm Peroxisome membrane Peripheral membrane protein Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).


该产品尚未在任何出版物中被引用。

[1].
"Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19."

[2].
"The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14."

[3].
"Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5."

[4].
"Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients."

[5].
"PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import."

[6].
"Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders."

[7].
"Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders."

[8].
"A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform."

[9].
"Genotype-phenotype correlation in PEX5-deficient peroxisome biogenesis defective cell lines."

[10].
"Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure."
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