首页 > 重组蛋白 > Human PLK2 Recombinant Protein

PLK2 (基因名), Serine/threonine-protein kinase PLK2 (蛋白名), plk2_human.

产品名称:

Human PLK2/ Serine/threonine-protein kinase PLK2 Recombinant Protein
丝氨酸/ threonine-protein激酶PLK2

货号:

R12869h

商标:

EIAab^®

监管等级:

RUO

别名:

Polo-like kinase 2, Serine/threonine-protein kinase SNK, Serum-inducible kinase, PLK-2, hSNK, SNK

序列号:

Q9NYY3

来源:

E.coli

种属:

Human

标签:

His

序列:

Recombinant protein

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Signal Transduction

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 5q11.2 by HGNC 5q11.2 by Entrez Gene 5q11.2 by Ensembl

PLK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with NSF; causing NSF dissociation from GRIA2. Interacts with CIB1.

功能:

Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

亚细胞位置:

Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriole Cell projection Dendrite Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.

数据库链接

UniGene:

Hs.398157

SMR:

Q9NYY3

STRING:

9606.ENSP00000274289

KEGG:

hsa:10769

MIM:

607023

Pfam:

PF00069

Uniprot:

Q9NYY3

相关产品

序列长度:

685

序列:

仅供参考，详细请咨询（services@eiaab.com）

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685:

ISTTFRLTTL | LMSGCSSELK | NRMEYALNML | LQRCN

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain."

(PMID: 19001868)

[2].

"Polo-like kinase-2 is required for centriole duplication in mammalian cells."

(PMID: 15242618)

[3].

"Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase."

(PMID: 11696980)

[4].

"Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells."

(PMID: 11716500)

[5].

"Centrosome-related genes, genetic variation, and risk of breast cancer."

(PMID: 20508983)

[6].

"Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions."

(PMID: 21340720)

[7].

"PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle."

(PMID: 20531387)

[8].

"Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication."

(PMID: 20352051)

[9].

"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging."

(PMID: 19834535)

[10].

"The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions."

(PMID: 20054236)

[1].

人丝氨酸/ threonine-protein激酶PLK2(PLK2)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人丝氨酸/ threonine-protein激酶PLK2(PLK2)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人丝氨酸/ threonine-protein激酶PLK2(PLK2)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人丝氨酸/ threonine-protein激酶PLK2(PLK2)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人丝氨酸/ threonine-protein激酶PLK2(PLK2)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人丝氨酸/ threonine-protein激酶PLK2(PLK2)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人丝氨酸/ threonine-protein激酶PLK2(PLK2)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人丝氨酸/ threonine-protein激酶PLK2(PLK2)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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