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PLN (基因名), Cardiac phospholamban (蛋白名), ppla_human.
产品名称:

Human PLN/ Cardiac phospholamban Recombinant Protein
心脏受磷蛋白

货号:

R1884h

商标:
EIAab®
监管等级:
别名:

PLB, PLB

序列号:
P26678
来源:
E.coli
种属:
Human
标签:
His
序列:
CIEMPQQARQ
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human PLN Protein
规格 & 价格: cart
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Human PLN Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 6q22.31 by HGNC 6q22.31 by Entrez Gene 6q22.31 by Ensembl
PLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homopentamer (PubMed:16043693, PubMed:16897780). Interacts with HAX1 and ATP2A2 (PubMed:17241641).


功能:
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.


亚细胞位置:
Endoplasmic reticulum membrane Single-pass membrane protein Sarcoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein Membrane Single-pass membrane protein Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).


该产品尚未在任何出版物中被引用。

[1].
"[Association between phospholamban gene mutation and dilated cardiomyopathy in the Chengdu area]."

[2].
"Phospholamban gene mutations are not associated with hypertrophic cardiomyopathy in a Northern Greek population."

[3].
"[Association between mutation of phospholamban gene and dilated cardiomyopathy]."

[4].
"Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy."

[5].
"Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6."

[6].
"Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy."

[7].
"Mutations in the human phospholamban gene in patients with heart failure."

[8].
"PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing."

[9].
"A novel custom resequencing array for dilated cardiomyopathy."

[10].
"Common variants at ten loci influence QT interval duration in the QTGEN Study."
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