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HRAS (基因名), GTPase HRas (蛋白名), rash_human.
产品名称:

Human HRAS/ GTPase HRas Recombinant Protein
GTP酶HRas

货号:

R1294h

商标:
EIAab®
监管等级:
别名:

H-Ras-1, Ha-Ras, Transforming protein p21, c-H-ras, p21ras, HRAS1

序列号:
P01112
来源:
E.coli
种属:
Human
标签:
His
序列:
1-186aa
预估分子量:
20.46 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human HRAS Protein
规格 & 价格: cart
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Human HRAS Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human HRAS Protein
Recombinant human HRAS protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 11p15.5 by HGNC 11p15.5 by Entrez Gene 11p15.5 by Ensembl
HRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
In its GTP-bound form interacts with PLCE1 (PubMed:11022048). Interacts with TBC1D10C (PubMed:17230191). Interacts with RGL3 (By similarity). Interacts with HSPD1 (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ (PubMed:11257115). Interacts with RASSF5 (PubMed:18596699). Interacts with PDE6D (PubMed:11980706). Interacts with IKZF3 (PubMed:10369681). Interacts with RACK1 (PubMed:14500341). Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity). Interacts with RAPGEF2 (PubMed:10608844, PubMed:11598133).


功能:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.


亚细胞位置:
Isoform 2 Nucleus Cytoplasm Cytoplasm Perinuclear region Colocalizes with RACK1 to the perinuclear region.


该产品尚未在任何出版物中被引用。

[1].
"Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome."

[2].
"Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas."

[3].
"Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension."

[4].
"Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns."

[5].
"The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer."

[6].
"Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients."

[7].
"[Study on association between an H-RAS gene polymorphism and gastric cancer development]."

[8].
"BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance."

[9].
"Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells."

[10].
"Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade."
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