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首页  >  重组蛋白  >  Human SLC26A5 Recombinant Protein
SLC26A5 (基因名), Prestin (蛋白名), s26a5_human.
产品名称:

Human SLC26A5/ Prestin Recombinant Protein
前列素

货号:

R15288h

商标:
EIAab®
监管等级:
别名:

Solute carrier family 26 member 5, PRES

序列号:
P58743
来源:
E.coli
种属:
Human
标签:
His
序列:
556-636aa
预估分子量:
8.91 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SLC26A5 Protein
规格 & 价格: cart
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Human SLC26A5 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
Human SLC26A5 Protein
Recombinant human SLC26A5 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
通用注释


亚单元:
N/A


功能:
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site.


亚细胞位置:
Cell membrane Multi-pass membrane protein Lateral wall of outer hair cells.


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