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SESN3 (基因名), Sestrin-3 (蛋白名), sesn3_human.
产品名称:

Human SESN3/ Sestrin-3 Recombinant Protein
Sestrin-3

货号:

R0299h

商标:
EIAab®
监管等级:
别名:

SEST3

序列号:
P58005
来源:
E.coli
种属:
Human
标签:
His
序列:
310-492aa
预估分子量:
20.13 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SESN3 Protein
规格 & 价格: cart
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Human SESN3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q21 by HGNC 11q21 by Entrez Gene 11q21 by Ensembl
SESN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by leucine (PubMed:25263562, PubMed:26449471). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). Interacts with the TORC2 complex; through RICTOR.


功能:
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse."

[2].
"Sestrin2 is a leucine sensor for the mTORC1 pathway."

[3].
"The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1."

[4].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[5].
"Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability."

[6].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging."

[9].
"Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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