首页 > 重组蛋白 > Human SIGMAR1 Recombinant Protein

SIGMAR1 (基因名), Sigma non-opioid intracellular receptor 1 (蛋白名), sgmr1_human.

产品名称:

Human SIGMAR1/ Sigma non-opioid intracellular receptor 1 Recombinant Protein
sigma非阿片细胞内受体1

货号:

R5642h

商标:

EIAab^®

监管等级:

RUO

别名:

Aging-associated gene 8 protein, SR31747-binding protein, Sigma 1-type opioid receptor, SR-BP, SIG-1R, AAG8, OPRS1, SRBP

序列号:

Q99720

来源:

E.coli

种属:

Human

标签:

His

序列:

114-223aa

预估分子量:

12.1 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human SIGMAR1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 9p13.3 by HGNC 9p13.3 by Entrez Gene 9p13.3 by Ensembl

SIGMAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homotrimer (PubMed:27042935). Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4 (By similarity). Interacts with KCNA2; cocaine consumption leads to increased interaction.

功能:

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria.

亚细胞位置:

Nucleus inner membrane Nucleus outer membrane Nucleus envelope Cytoplasmic vesicle Endoplasmic reticulum membrane Membrane Single-pass membrane protein Lipid droplet Cell junction Cell membrane Cell projection Growth cone Cell junction Synapse Postsynaptic cell membrane Postsynaptic density During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (PubMed:10406945). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic reticulum is prominent in alpha-motor neurons of patients with amyotrophic lateral sclerosis (PubMed:23314020). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity).

数据库链接

UniGene:

Hs.522087

SMR:

Q99720

STRING:

9606.ENSP00000277010

KEGG:

hsa:10280

MIM:

601978

Pfam:

PF04622

Uniprot:

Q99720

相关产品

Mouse Sigmar1 ELISA Kit

Rat Sigmar1 ELISA Kit

Bovine SIGMAR1 ELISA Kit

Chicken SIGMAR1 ELISA Kit

Mouse Sigmar1 CLIA Kit

序列长度:

223

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

223:

YTLRSYARGL | RLELTTYLFG | QDP

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands."

(PMID: 25510962)

[2].

"Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease."

(PMID: 25449906)

[3].

"AAG8 promotes carcinogenesis by activating STAT3."

(PMID: 24726897)

[4].

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."

(PMID: 24275569)

[5].

"Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke."

(PMID: 25261976)

[6].

"HIV-1/cocaine induced oxidative stress disrupts tight junction protein-1 in human pulmonary microvascular endothelial cells: role of Ras/ERK1/2 pathway."

(PMID: 24409324)

[7].

"Characterization of recombinant ELMOD (cell engulfment and motility domain) proteins as GTPase-activating proteins (GAPs) for ARF family GTPases."

(PMID: 24616099)

[8].

"A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF?)."

(PMID: 25266722)

[9].

"Modeling tandem AAG8-MEK inhibition in melanoma cells."

(PMID: 24634165)

[10].

"Overexpression of Sig1R is closely associated with tumor progression and poor outcome in patients with hilar cholangiocarcinoma."

(PMID: 25344871)

[1].

人sigma非阿片细胞内受体1(SIGMAR1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人sigma非阿片细胞内受体1(SIGMAR1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人sigma非阿片细胞内受体1(SIGMAR1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人sigma非阿片细胞内受体1(SIGMAR1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人sigma非阿片细胞内受体1(SIGMAR1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人sigma非阿片细胞内受体1(SIGMAR1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人sigma非阿片细胞内受体1(SIGMAR1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人sigma非阿片细胞内受体1(SIGMAR1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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