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SIRT2 (基因名), NAD-dependent deacetylase sirtuin-2 (蛋白名), sirt2_human.
产品名称:

Human SIRT2/ NAD-dependent deacetylase sirtuin-2 Recombinant Protein
NAD依赖脱乙酰基酶2

货号:

R0430h

商标:
EIAab®
监管等级:
别名:

SIR2-like protein 2, SIR2L, SIR2L2

序列号:
Q8IXJ6
来源:
E.coli
种属:
Human
标签:
His
序列:
65-340aa
预估分子量:
30.36 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Epigenetics
Human SIRT2 Protein
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Human SIRT2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19q13.2 by HGNC 19q13.2 by Entrez Gene 19q13.2 by Ensembl
SIRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton.


功能:
NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.


亚细胞位置:
Cytoplasm cytoskeleton Colocalizes with microtubules.


该产品尚未在任何出版物中被引用。

[1].
"Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2."

[2].
"The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility."

[3].
"Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin."

[4].
"Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation."

[5].
"Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene."

[6].
"Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle."

[7].
"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase."

[8].
"Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity."

[9].
"Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition."

[10].
"Selective Sirt2 inhibition by ligand-induced rearrangement of the active site."
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