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SMYD3 (基因名), Histone-lysine N-methyltransferase SMYD3 (蛋白名), smyd3_human.
产品名称:

Human SMYD3/ Histone-lysine N-methyltransferase SMYD3 Recombinant Protein

货号:

R3352h

商标:
EIAab®
监管等级:
别名:

SET and MYND domain-containing protein 3, Zinc finger MYND domain-containing protein 1, ZMYND1, ZNFN3A1

序列号:
Q9H7B4
来源:
E.coli
种属:
Human
标签:
His
序列:
1-240aa
预估分子量:
26.4 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SMYD3 Protein
规格 & 价格: cart
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Human SMYD3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human SMYD3 Protein
Recombinant human SMYD3 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 1q44 by HGNC 1q44 by Entrez Gene 1q44 by Ensembl
SMYD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with HSPCA (PubMed:15235609). Interacts with HELZ (PubMed:15235609). Interacts with POLR2A; the interaction may be indirect and may be mediated by HELZ (PubMed:15235609). Interacts with HSP90AA1; this interaction enhances SMYD3 histone-lysine N-methyltransferase (PubMed:25738358).


功能:
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).


亚细胞位置:
Cytoplasm Nucleus Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.


该产品尚未在任何出版物中被引用。

[1].
"SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells."

[2].
"C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis."

[3].
"Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation."

[4].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[5].
"Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking."
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