首页 > 重组蛋白 > Human SNAP25 Recombinant Protein

SNAP25 (基因名), Synaptosomal-associated protein 25 (蛋白名), snp25_human.

产品名称:

Human SNAP25/ Synaptosomal-associated protein 25 Recombinant Protein
突触小体相关蛋白25

货号:

R15057h

商标:

EIAab^®

监管等级:

RUO

别名:

Super protein, Synaptosomal-associated 25 kDa protein, SUP, SNAP-25, SNAP

序列号:

P60880

来源:

E.coli

种属:

Human

标签:

His

序列:

1-206aa

预估分子量:

22.66 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Signal Transduction

规格 & 价格:

关注

Human SNAP25 Protein

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

Recombinant human SNAP25 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 20p12.2 by HGNC 20p12.2 by Entrez Gene 20p12.2 by Ensembl

SNAP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1 (PubMed:11832227). Found in a complex containing SYT1, SV2B and syntaxin-1 (By similarity). Found in a ternary complex with STX1A and VAMP8 (By similarity). Isoform 1 and isoform 2 interact with BLOC1S6 (PubMed:19546860). Interacts with CENPF (By similarity). Interacts with EQTN (By similarity). Interacts with HGS (By similarity). Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells (By similarity). Interacts with OTOF (By similarity). Interacts with RIMS1 (By similarity). Interacts with SNAPIN (By similarity). Interacts with STXBP6 (By similarity). Interacts with TRIM9 (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (By similarity). Associates with the BLOC-1 complex (PubMed:19546860).

功能:

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

亚细胞位置:

Cytoplasm Perinuclear region Cell membrane Lipid-anchor Cell junction Synapse Synaptosome Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity).

数据库链接

UniGene:

Hs.167317

SMR:

P60880

STRING:

9606.ENSP00000254976

KEGG:

hsa:6616

MIM:

600322

Pfam:

PF00835

Uniprot:

P60880

相关产品

Mouse Snap25 ELISA Kit

Rat Snap25 ELISA Kit

Bovine SNAP25 ELISA Kit

Chicken SNAP25 ELISA Kit

Mouse Snap25 CLIA Kit

序列长度:

206

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

206:

KMLGSG

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Evidence that putative ADHD low risk alleles at SNAP25 may increase the risk of schizophrenia."

(PMID: 19132710)

[2].

"SNAP-25 genotype influences NAA/Cho in left hippocampus."

(PMID: 18726138)

[3].

"[Association between SNAP-25 gene polymorphism and attention deficit hyperactivity disorder]."

(PMID: 19099826)

[4].

"Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics."

(PMID: 18347838)

[5].

"No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population."

(PMID: 18512733)

[6].

"The SNAP-25 gene is associated with cognitive ability: evidence from a family-based study in two independent Dutch cohorts."

(PMID: 16801949)

[7].

"The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia."

(PMID: 15823421)

[8].

"The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes."

(PMID: 10692432)

[9].

"Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2."

(PMID: 8760387)

[10].

"Mutant SNAP25B causes myasthenia, cortical hyperexcitability, ataxia, and intellectual disability."

(PMID: 25381298)

[1].

人突触小体相关蛋白25(SNAP25)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人突触小体相关蛋白25(SNAP25)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人突触小体相关蛋白25(SNAP25)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人突触小体相关蛋白25(SNAP25)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人突触小体相关蛋白25(SNAP25)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人突触小体相关蛋白25(SNAP25)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人突触小体相关蛋白25(SNAP25)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人突触小体相关蛋白25(SNAP25)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

反馈墙

评论数 : 0

所有用户