EIAab
首页  >  重组蛋白  >  Human SORL1 Recombinant Protein
SORL1 (基因名), Sortilin-related receptor (蛋白名), sorl_human.
产品名称:

Human SORL1/ Sortilin-related receptor Recombinant Protein
分拣蛋白相关受体

货号:

R5512h

商标:
EIAab®
监管等级:
别名:

Low-density lipoprotein receptor relative with 11 ligand-binding repeats, SorLA-1, Sorting protein-related receptor containing LDLR class A repeats, LDLR relative with 11 ligand-binding repeats, SorLA, C11orf32

序列号:
Q92673
来源:
E.coli
种属:
Human
标签:
His
序列:
227-370aa
预估分子量:
15.84 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human SORL1 Protein
规格 & 价格: cart
×
Human SORL1 Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human SORL1 Protein
Recombinant human SORL1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 11q24.1 by HGNC 11q24.1 by Entrez Gene 11q24.1 by Ensembl
SORL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with GGA1 and ROCK2. Interacts with PLAUR. Interacts with APP.


功能:
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.


亚细胞位置:
Membrane Single-pass type I membrane protein Golgi apparatus Endosome Secreted


该产品尚未在任何出版物中被引用。

[1].
"A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens."

[2].
"Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein."

[3].
"Meta-analysis of the association between variants in SORL1 and Alzheimer disease."

[4].
"Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain."

[5].
"Implication of sex and SORL1 variants in italian patients with Alzheimer disease."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
通知
new 咨询
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com