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Sphk1 (基因名), Sphingosine kinase 1 (蛋白名), sphk1_mouse.
产品名称:

Mouse Sphk1/ Sphingosine kinase 1 Recombinant Protein
鞘氨醇激酶1

货号:

R2161m

商标:
EIAab®
监管等级:
别名:

Acetyltransferase SPHK1, SK 1, Sk1

序列号:
Q8CI15
来源:
E.coli
种属:
Mouse
标签:
His
序列:
12-159aa
预估分子量:
16.28 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Mouse Sphk1 Protein
规格 & 价格: cart
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Mouse Sphk1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Interacts with ACY1 (PubMed:15196915). Binds to calmodulin. Interacts with SPHKAP (By similarity). Interacts with CIB1, the interaction occurs in a calcium-dependent manner (By similarity). Interacts with TRAF2 (By similarity). Interacts with EEF1A1; the interaction enhances SPHK1 kinase activity (By similarity).


功能:
Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.


亚细胞位置:
Cytoplasm Endosome membrane Peripheral membrane protein Nucleus Cell membrane Cell junction Synapse Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner. Binds to membranes containing negatively charged lipids but not neutral lipids (By similarity). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (PubMed:27806293).


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