首页 > 重组蛋白 > Human SRSF3 Recombinant Protein

SRSF3 (基因名), Serine/arginine-rich splicing factor 3 (蛋白名), srsf3_human.

产品名称:

Human SRSF3/ Serine/arginine-rich splicing factor 3 Recombinant Protein
丝氨酸/精氨酸富有剪接因子2

货号:

R11551h

商标:

EIAab^®

监管等级:

RUO

别名:

Pre-mRNA-splicing factor SRP20, Splicing factor, arginine/serine-rich 3, SFRS3, SRP20

序列号:

P84103

来源:

E.coli

种属:

Human

标签:

His

序列:

1-90aa

预估分子量:

9.9 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Epigenetics

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human SRSF3 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 6p21.31-p21.2 by HGNC 6p21.31-p21.2 by Entrez Gene 6p21.31-p21.2 by Ensembl

SRSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with CPSF6 (PubMed:15169763). Interacts with RBMY1A1 (PubMed:15595951). Interacts with SREK1/SFRS12 (PubMed:10757789). Interacts with NXF1 (PubMed:12667464, PubMed:17036044). Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:26876937).

功能:

Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export such as of histone H2A (PubMed:11336712, PubMed:18364396). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). RNA-binding is semi-sequence specific (PubMed:17036044).

亚细胞位置:

Nucleus Nucleus speckle Cytoplasm Recruited to nuclear speckles following interaction with YTHDC1.

数据库链接

UniGene:

Hs.405144

SMR:

P84103

STRING:

9606.ENSP00000362820

KEGG:

hsa:6428

MIM:

603364

Pfam:

PF00076

Uniprot:

P84103

相关产品

Mouse Srsf3 ELISA Kit

Bovine SRSF3 ELISA Kit

Mouse Srsf3 CLIA Kit

Bovine SRSF3 CLIA Kit

Mouse Srsf3 Protein

序列长度:

164

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

164:

FSRSRSRSRS | NERK

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8."

(PMID: 17036044)

[2].

"Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA."

(PMID: 11336712)

[3].

"SR proteins: a conserved family of pre-mRNA splicing factors."

(PMID: 1577277)

[4].

"YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs."

(PMID: 28984244)

[5].

"Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing."

(PMID: 26876937)

[6].

"A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)."

(PMID: 20516191)

[7].

"Control of the papillomavirus early-to-late switch by differentially expressed SRp20."

(PMID: 18945760)

[8].

"Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation."

(PMID: 19250906)

[9].

"SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing."

(PMID: 19047369)

[10].

"Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP."

(PMID: 18364396)

[1].

人丝氨酸/精氨酸富有剪接因子2(SRSF3)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人丝氨酸/精氨酸富有剪接因子2(SRSF3)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人丝氨酸/精氨酸富有剪接因子2(SRSF3)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人丝氨酸/精氨酸富有剪接因子2(SRSF3)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人丝氨酸/精氨酸富有剪接因子2(SRSF3)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人丝氨酸/精氨酸富有剪接因子2(SRSF3)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人丝氨酸/精氨酸富有剪接因子2(SRSF3)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人丝氨酸/精氨酸富有剪接因子2(SRSF3)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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