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SWAP70 (基因名), Switch-associated protein 70 (蛋白名), swp70_human.
产品名称:

Human SWAP70/ Switch-associated protein 70 Recombinant Protein
开关相关蛋白70

货号:

R3416h

商标:
EIAab®
监管等级:
别名:

HSPC321, SWAP-70, KIAA0640

序列号:
Q9UH65
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human SWAP70 Protein
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Human SWAP70 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11p15.4 by HGNC 11p15.4 by Entrez Gene 11p15.4 by Ensembl
SWAP70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.


功能:
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.


亚细胞位置:
Cytoplasm Cell membrane Nucleus Cell projection Lamellipodium Cytoplasm Cytoskeleton In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).


该产品尚未在任何出版物中被引用。

[1].
"Association of SWAP-70 with the B cell antigen receptor complex."

[2].
"SWAP-70 identifies a transitional subset of actin filaments in motile cells."

[3].
"Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency."

[4].
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."

[5].
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."

[6].
"Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation."

[7].
"Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells."

[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[9].
"Expression of switch-associated protein 70 is associated with lymphocyte activation and reduced disability in multiple sclerosis."

[10].
"SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis."
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