首页 > 重组蛋白 > Human TACC3 Recombinant Protein

TACC3 (基因名), Transforming acidic coiled-coil-containing protein 3 (蛋白名), tacc3_human.

产品名称:

Human TACC3/ Transforming acidic coiled-coil-containing protein 3 Recombinant Protein

货号:

R16086h

商标:

EIAab^®

监管等级:

RUO

别名:

ERIC-1, ERIC1

序列号:

Q9Y6A5

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

关注

Human TACC3 Protein

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 4p16.3 by HGNC 4p16.3 by Entrez Gene 4p16.3 by Ensembl

TACC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with microtubules. Interacts with CKAP5 independently of clathrin. Interacts with CKAP5 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; TACC3 (phosphorylated at Ser-558 by AURKA) and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582, PubMed:23918938, PubMed:25596274). Interacts with CCDC100/CEP120. The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF (PubMed:14767476).

功能:

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).

亚细胞位置:

Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasm Cytoskeleton Spindle Cytoplasm Cytoskeleton Spindle pole In complex with CKAP5 localized to microtuble plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.

数据库链接

UniGene:

Hs.104019

SMR:

Q9Y6A5

STRING:

9606.ENSP00000326550

KEGG:

hsa:10460

MIM:

605303

Pfam:

PF05010

Uniprot:

Q9Y6A5

相关产品

Mouse Tacc3 ELISA Kit

Mouse Tacc3 CLIA Kit

Mouse Tacc3 Protein

Mouse Tacc3 Polyclonal Antibody

Mouse Tacc3 Monoclonal Antibody

序列长度:

838

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

838:

RKEQMRIQSL | EKTVEQKTKE | NEELTRICDD | LISKMEKI

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival."

(PMID: 17675670)

[2].

"The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines."

(PMID: 10366448)

[3].

"Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension."

(PMID: 23532825)

[4].

"Centrosome-related genes, genetic variation, and risk of breast cancer."

(PMID: 20508983)

[5].

"A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging."

(PMID: 21297582)

[6].

"A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer."

(PMID: 20348956)

[7].

"A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci."

(PMID: 20972438)

[8].

"Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells."

(PMID: 19148534)

[9].

"NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment."

(PMID: 17060449)

[10].

"Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity."

(PMID: 17545617)

[1].

人TACC3重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人TACC3重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人TACC3重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人TACC3重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人TACC3重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人TACC3重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人TACC3重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人TACC3重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

反馈墙

评论数 : 0

所有用户

默认排序