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TEAD4 (基因名), Transcriptional enhancer factor TEF-3 (蛋白名), tead4_human.
产品名称:

Human TEAD4/ Transcriptional enhancer factor TEF-3 Recombinant Protein

货号:

R3437h

商标:
EIAab®
监管等级:
别名:

TEA domain family member 4, Transcription factor 13-like 1, Transcription factor RTEF-1, TEAD-4, RTEF1, TCF13L1, TEF3

序列号:
Q15561
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human TEAD4 Protein
规格 & 价格: cart
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Human TEAD4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12p13.33 by HGNC 12p13.33 by Entrez Gene 12p13.33 by Ensembl
TEAD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with YAP1 and WWTR1/TAZ.


功能:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family."

[2].
"TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition."

[3].
"TEAD mediates YAP-dependent gene induction and growth control."

[4].
"Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells."

[5].
"Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation."

[6].
"Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis."

[7].
"A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain."

[8].
"Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis."

[9].
"[Clinical features of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions-single-center study]."

[10].
"Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor."
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