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TEP1 (基因名), Telomerase protein component 1 (蛋白名), tep1_human.
产品名称:

Human TEP1/ Telomerase protein component 1 Recombinant Protein
端粒

货号:

R0558h

商标:
EIAab®
监管等级:
别名:

Telomerase-associated protein 1, p240, p80 telomerase homolog, Telomerase protein 1, TLP1, TP1

序列号:
Q99973
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human TEP1 Protein
规格 & 价格: cart
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Human TEP1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 14q11.2 by HGNC 14q11.2 by Entrez Gene 14q11.2 by Ensembl
TEP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.


功能:
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.


亚细胞位置:
Nucleus Chromosome Telomere


该产品尚未在任何出版物中被引用。

[1].
"Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis."

[2].
"Genetic variation in five genes important in telomere biology and risk for breast cancer."

[3].
"Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding."

[4].
"Vaults and telomerase share a common subunit, TEP1."

[5].
"Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases."
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