首页 > 重组蛋白 > Human TERF2 Recombinant Protein

TERF2 (基因名), Telomeric repeat-binding factor 2 (蛋白名), terf2_human.

产品名称:

Human TERF2/ Telomeric repeat-binding factor 2 Recombinant Protein

货号:

R11788h

商标:

EIAab^®

监管等级:

RUO

别名:

TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein, TRBF2, TRF2

序列号:

Q15554

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human TERF2 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 16q22.1 by HGNC 16q22.1 by Entrez Gene 16q22.1 by Ensembl

TERF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP/RAP1, ACD and POT1. Interacts with TERF2IP. Interacts with NBN. Interacts with SLX4/BTBD12. Interacts with DCLRE1B/Apollo and TERF2IP/RAP1; the interaction is direct.

功能:

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.

亚细胞位置:

Nucleus Chromosome Telomere Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.

数据库链接

UniGene:

Hs.63335

SMR:

Q15554

STRING:

9606.ENSP00000254942

KEGG:

hsa:7014

MIM:

602027

Pfam:

PF00249

Uniprot:

Q15554

相关产品

Mouse Terf2 ELISA Kit

Chicken TERF2 ELISA Kit

Mouse Terf2 CLIA Kit

Chicken TERF2 CLIA Kit

Mouse Terf2 Protein

序列长度:

542

序列:

仅供参考，详细请咨询（services@eiaab.com）

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542:

KAGVQKYGEG | NWAAISKNYP | FVNRTAVMIK | DRWRTMKRLG | MN

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2."

(PMID: 9326950)

[2].

"Arginine methylation regulates telomere length and stability."

(PMID: 19596784)

[3].

"The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair."

(PMID: 16730175)

[4].

"How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures."

(PMID: 15608617)

[5].

"Shelterin: the protein complex that shapes and safeguards human telomeres."

(PMID: 16166375)

[6].

"DNA damage-induced phosphorylation of the human telomere-associated protein TRF2."

(PMID: 16223874)

[7].

"TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."

(PMID: 15316005)

[8].

"Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins."

(PMID: 15383534)

[9].

"Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2."

(PMID: 11545737)

[10].

"Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres."

(PMID: 10888888)

[1].

人TERF2重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人TERF2重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人TERF2重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人TERF2重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人TERF2重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人TERF2重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人TERF2重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人TERF2重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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