首页 > 重组蛋白 > Human TIMP1 Recombinant Protein

TIMP1 (基因名), Metalloproteinase inhibitor 1 (蛋白名), timp1_human.

产品名称:

Human TIMP1/ Metalloproteinase inhibitor 1 Recombinant Protein
金属蛋白酶抑制剂1

货号:

R0552h

商标:

EIAab^®

监管等级:

RUO

别名:

Erythroid-potentiating activity, Fibroblast collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, EPA, Collagenase inhibitor, TIMP-1, CLGI, TIMP

序列号:

P01033

来源:

E.coli

种属:

Human

标签:

His

序列:

24-207aa

预估分子量:

20.24 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cardiovascular

规格 & 价格:

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Human TIMP1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The sequence analysis of human TIMP1 protein including hydrophilcity, hydrophobicity and antigenicity.

Recombinant human TIMP1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: Xp11.3 by HGNC Xp11.3 by Entrez Gene Xp11.3 by Ensembl

TIMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1.

功能:

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.522632

SMR:

P01033

STRING:

9606.ENSP00000218388

KEGG:

hsa:7076

MIM:

305370

Pfam:

PF00965

Uniprot:

P01033

相关产品

Mouse Timp1 ELISA Kit

Rat Timp1 ELISA Kit

Bovine TIMP1 ELISA Kit

Pig TIMP1 ELISA Kit

Dog TIMP1 ELISA Kit

序列长度:

207

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

210:

TWQSLRSQIA |

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"The protective effect of xanthan gum on interleukin-1β induced rabbit chondrocytes"

G Han, H Shao, X Zhu, et al.

From: Carbohydrate Polymers

[1].

"Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein."

(PMID: 16917503)

[2].

"Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease."

(PMID: 12218659)

[3].

"NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases."

(PMID: 10623524)

[4].

"TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling."

(PMID: 24635319)

[5].

"Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation."

(PMID: 23522389)

[6].

"Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure."

(PMID: 22427646)

[7].

"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."

(PMID: 20587546)

[8].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[9].

"Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes."

(PMID: 20452482)

[10].

"A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)."

(PMID: 20673868)

[1].

人金属蛋白酶抑制剂1(TIMP1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人金属蛋白酶抑制剂1(TIMP1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人金属蛋白酶抑制剂1(TIMP1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人金属蛋白酶抑制剂1(TIMP1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人金属蛋白酶抑制剂1(TIMP1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人金属蛋白酶抑制剂1(TIMP1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人金属蛋白酶抑制剂1(TIMP1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人金属蛋白酶抑制剂1(TIMP1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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