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TLN1 (基因名), Talin-1 (蛋白名), tln1_human.
产品名称:

Human TLN1/ Talin-1 Recombinant Protein
Talin-1

货号:

R2104h

商标:
EIAab®
监管等级:
别名:

KIAA1027, TLN

序列号:
Q9Y490
来源:
E.coli
种属:
Human
标签:
His
序列:
2293-2533aa
预估分子量:
26.51 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human TLN1 Protein
规格 & 价格: cart
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Human TLN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 9p13.3 by HGNC 9p13.3 by Entrez Gene 9p13.3 by Ensembl
TLN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds with high affinity to VCL and with low affinity to integrins. Interacts with APBB1IP; this inhibits VCL binding. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with human cytomegalovirus protein UL135.


功能:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.


亚细胞位置:
Cell projection Ruffle membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cytoskeleton Cell surface Cell junction Focal adhesion Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).


该产品尚未在任何出版物中被引用。

[1].
"Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern."

[2].
"ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene."

[3].
"Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin."

[4].
"Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1."

[5].
"Structural basis for amplifying vinculin activation by talin."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha."

[8].
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."

[9].
"Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions."

[10].
"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
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