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TLR5 (基因名), Toll-like receptor 5 (蛋白名), tlr5_human.
产品名称:

Human TLR5/ Toll-like receptor 5 Recombinant Protein
Toll样受体5

货号:

R1990h

商标:
EIAab®
监管等级:
别名:

Toll/interleukin-1 receptor-like protein 3, TIL3

序列号:
O60602
来源:
E.coli
种属:
Human
标签:
His
序列:
661-858aa
预估分子量:
21.78 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human TLR5 Protein
规格 & 价格: cart
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Human TLR5 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1q41 by HGNC 1q41 by Entrez Gene 1q41 by Ensembl
TLR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand.


功能:
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.


亚细胞位置:
Membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus."

[2].
"A history of recurrent positive selection at the toll-like receptor 5 in primates."

[3].
"Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus."

[4].
"Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease."

[5].
"Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer."

[6].
"Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin."

[7].
"Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus."

[8].
"Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease."

[9].
"Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam."

[10].
"A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease."
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