TLR9 (基因名), Toll-like receptor 9 (蛋白名), tlr9_human.
产品名称:
Human TLR9/ Toll-like receptor 9 Recombinant Protein
Toll样受体9
货号:
R0709h
商标:
EIAab®
监管等级:
别名:
CD289, UNQ5798/PRO19605
序列号:
Q9NR96
来源:
E.coli
种属:
Human
标签:
His
序列:
840-1032aa
预估分子量:
21.23 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
R&D 技术数据
更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.
基因位点
TLR9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
通用注释
亚单元:
Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B.
功能:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
亚细胞位置:
Endoplasmic reticulum membrane
Single-pass type I membrane protein
Endosome
Lysosome
Cytoplasmic vesicle
Phagosome
Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
数据库链接
验证序列:
该产品尚未在任何出版物中被引用。
[1].
"Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese."
[2].
"TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression."
[3].
"Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population."
[5].
"Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity."
[6].
"Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus."
[7].
"Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis."
[8].
"Common human Toll-like receptor 9 polymorphisms and haplotypes: association with atopy and functional relevance."
[9].
"Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner."
[10].
"Three novel mammalian toll-like receptors: gene structure, expression, and evolution."
[1].
人Toll样受体9(TLR9)重组蛋白是否是无菌的？
蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。
[2].
人Toll样受体9(TLR9)重组蛋白的保存缓冲液是什么？
纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。
[3].
怎样确定人Toll样受体9(TLR9)重组蛋白的浓度？
蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。
[4].
人Toll样受体9(TLR9)重组蛋白蛋白保存条件是怎样的？
蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。
[5].
人Toll样受体9(TLR9)重组蛋白是否可以用于活体实验？
重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。
[6].
人Toll样受体9(TLR9)重组蛋白的保质期是多久？
在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。
[7].
你们蛋白和抗体的报价是怎么样的？
我们将根据你需要的蛋白和抗体的大小进行报价。
[8].
人Toll样受体9(TLR9)重组蛋白是否能够提供蛋白片段？
我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。
[9].
人Toll样受体9(TLR9)重组蛋白的货期或发货时间一般是多长？
具体指标的货期需要确定。最快一周，最长可能一个月。
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