首页 > 重组蛋白 > Human TNF Recombinant Protein

TNF (基因名), Tumor necrosis factor (蛋白名), tnfa_human.

产品名称:

Human TNF/ Tumor necrosis factor Recombinant Protein
肿瘤坏死因子

货号:

R0133h

商标:

EIAab^®

监管等级:

RUO

别名:

Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, TNFA, TNFSF2

序列号:

P01375

来源:

E.coli

种属:

Human

标签:

His

序列:

63-215aa

预估分子量:

16.83 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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Human TNF Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 11 )
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

Recombinant human TNF protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 6p21.33 by HGNC 6p21.33 by Entrez Gene 6p21.33 by Ensembl

TNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homotrimer. Interacts with SPPL2B.

功能:

The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

亚细胞位置:

C-domain 2 Secreted

数据库链接

UniGene:

Hs.241570

SMR:

P01375

STRING:

9606.ENSP00000398698

KEGG:

hsa:7124

MIM:

191160

Pfam:

PF00229

Uniprot:

P01375

相关产品

序列长度:

233

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

233:

QLEKGDRLSA | EINRPDYLDF | AESGQVYFGI | IAL

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Extracellular Vesicles from Albumin-Induced Tubular Epithelial Cells Promote the M1 Macrophage Phenotype by Targeting Klotho"

Yj Jia, Zj Zheng, M Xue, et al.

From: Molecular Therapy

[2].

"Emodin relieves the inflammation and pyroptosis of lipopolysaccharide-treated 1321N1 cells by regulating methyltransferase-like 3 -mediated NLR family pyrin domain containing 3 expression"

B Wang, Y Liu, R Jiang, et al.

From: Bioengineered

[3].

"HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway"

Y Zeng, R He, Y Liu, et al.

From: Journal of Orthopaedic Surgery and Research

[4].

"Cord blood antimicrobial peptide LL37 levels in preterm neonates and association with preterm complications"

Zx Ren, Wh Mo, Ll Yang, et al.

From: Italian Journal of Pediatrics

[5].

"Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E"

G Tan, Cj Lin, Cy Huang, et al.

From: Cancer Letters

[6].

"Interleukin-27 enhances the production of tumour necrosis factor-α and interferon-γ by bone marrow T lymphocytes in aplastic anaemia"

JP Li, QJ Zhao, W Xing, et al.

From: British Journal of Haematology

[7].

"Effect of high-dose rosuvastatin loading before percutaneous coronary intervention in female patients with non-ST-segment elevation acute coronary..."

Y Gao, ZM Jia, YJ Sun, et al.

From: Chin Med J (Engl)

[8].

"Demethylation of tumor necrosis factor-α converting enzyme predicts poor prognosis in acute-on-chronic hepatitis B liver failure"

Wang Z L, Gao S, Li L, et al

From: Clinics and research in hepatology and gastroenterology

[9].

"Preclinical efficacy of Dexmedetomidine on spinal cord injury provoked oxidative renal damage"

Shou-Shi W, Ting-Ting S, Ji-Shun N, et al.

From: Renal failure

[10].

"Promoter methylation status and expression of PPAR-γ gene are associated with prognosis of acute-on-chronic hepatitis B liver failure"

Zhao Z H, Fan Y C, Zhao Q, et al.

From: Clinical epigenetics

[11].

"A genetic role for macrophage migration inhibitory factor (MIF) in Epinephelus awoara infected with Vibrio parahaemolyticus"

Xu X, Sang B, Luo G.

From: European Journal of Inflammation

[1].

"Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma."

(PMID: 20087644)

[2].

"Genetic susceptibility to different clinical forms of tuberculosis in the Peruvian population."

(PMID: 20188863)

[3].

"Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II."

(PMID: 19267370)

[4].

"The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality."

(PMID: 19242354)

[5].

"Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion."

(PMID: 19347053)

[1].

人肿瘤坏死因子(TNF)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人肿瘤坏死因子(TNF)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人肿瘤坏死因子(TNF)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人肿瘤坏死因子(TNF)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人肿瘤坏死因子(TNF)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人肿瘤坏死因子(TNF)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人肿瘤坏死因子(TNF)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人肿瘤坏死因子(TNF)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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