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TAPBP (基因名), Tapasin (蛋白名), tpsn_human.
产品名称:

Human TAPBP/ Tapasin Recombinant Protein

货号:

R16034h

商标:
EIAab®
监管等级:
别名:

NGS-17, TAP-associated protein, TAP-binding protein, TPN, NGS17, TAPA

序列号:
O15533
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human TAPBP Protein
规格 & 价格: cart
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Human TAPBP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 6p21.32 by HGNC 6p21.32 by Entrez Gene 6p21.32 by Ensembl
TAPBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterodimer with PDIA3; disulfide-linked. Interacts with TAP1 and is thus a subunit of the TAP complex, also known as the peptide loading complex (PLC). Interaction with TAP1 is TAP2-independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, PDIA3 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP.


功能:
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).


亚细胞位置:
Endoplasmic reticulum membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Cloning and functional characterization of a subunit of the transporter associated with antigen processing."

[2].
"Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia?"

[3].
"Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes."

[4].
"Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study."

[5].
"Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA."

[6].
"An essential function of tapasin in quality control of HLA-G molecules."

[7].
"A subject with a novel type I bare lymphocyte syndrome has tapasin deficiency due to deletion of 4 exons by Alu-mediated recombination."

[8].
"Tapasin is required for efficient peptide binding to transporter associated with antigen processing."

[9].
"Identification of novel Tapasin polymorphisms and linkage disequilibrium to MHC class I alleles."

[10].
"Granulocyte-macrophage colony-stimulating factor modulates tapasin expression in human neutrophils."
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