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TREM2 (基因名), Triggering receptor expressed on myeloid cells 2 (蛋白名), trem2_human.
产品名称:

Human TREM2/ Triggering receptor expressed on myeloid cells 2 Recombinant Protein
髓系细胞触发受体2

货号:

R12753h

商标:
EIAab®
监管等级:
别名:

Triggering receptor expressed on monocytes 2, TREM-2

序列号:
Q9NZC2
来源:
E.coli
种属:
Human
标签:
His
序列:
19-174aa
预估分子量:
17.16 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
  • Human TREM2 Protein
  • Human TREM2 Protein
  • Human TREM2 Protein
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Human TREM2 Protein
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human TREM2 Protein
The PCR product of human TREM2 gene was determined by 1% Agarose stained with EB.
Human TREM2 Protein
Recombinant human TREM2 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 6p21.1 by HGNC 6p21.1 by Entrez Gene 6p21.1 by Ensembl
TREM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with TYROBP/DAP12.


功能:
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.


亚细胞位置:
Isoform 3 Secreted


该产品尚未在任何出版物中被引用。

[1].
"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype."

[2].
"Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes."

[3].
"Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms."

[4].
"A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese."

[5].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
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