首页 > 重组蛋白 > Human THBS1 Recombinant Protein

THBS1 (基因名), Thrombospondin-1 (蛋白名), tsp1_human.

产品名称:

Human THBS1/ Thrombospondin-1 Recombinant Protein
血小板反应蛋白1

货号:

R0611h

商标:

EIAab^®

监管等级:

RUO

别名:

Glycoprotein G, TSP, TSP1

序列号:

P07996

来源:

E.coli

种属:

Human

标签:

His

序列:

CASGSSSNAKSYRAKMKKKGTT

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human THBS1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 15q14 by HGNC 15q14 by Entrez Gene 15q14 by Ensembl

THBS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain) (By similarity).

功能:

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

亚细胞位置:

Secreted Cell surface Secreted Extracellular space Extracellular matrix Endoplasmic reticulum Sarcoplasmic reticulum Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity).

数据库链接

UniGene:

Hs.164226

SMR:

P07996

STRING:

9606.ENSP00000260356

KEGG:

hsa:7057

MIM:

188060

Pfam:

PF00090

Uniprot:

P07996

相关产品

Mouse Thbs1 ELISA Kit

Bovine THBS1 ELISA Kit

Mouse Thbs1 CLIA Kit

Bovine THBS1 CLIA Kit

Mouse Thbs1 Protein

序列长度:

1170

序列:

仅供参考，详细请咨询（services@eiaab.com）

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1150:

1189:

ADSGPIYD K | TYAGGRLGLF | VFSQEMVFFS | DLKYECRDP

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication."

(PMID: 12391027)

[2].

"Aberrant methylation of thrombospondin-1 and its association with reduced expression in gastric cardia adenocarcinoma."

(PMID: 20300551)

[3].

"Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease."

(PMID: 20346360)

[4].

"Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes."

(PMID: 20452482)

[5].

"A Large-scale genetic association study of esophageal adenocarcinoma risk."

(PMID: 20453000)

[6].

"Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population."

(PMID: 20485444)

[7].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[8].

"A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)."

(PMID: 20673868)

[9].

"The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells."

(PMID: 20372793)

[10].

"Differential changes in platelet VEGF, Tsp, CXCL12, and CXCL4 in patients with metastatic cancer."

(PMID: 20182908)

[1].

人血小板反应蛋白1(THBS1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人血小板反应蛋白1(THBS1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人血小板反应蛋白1(THBS1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人血小板反应蛋白1(THBS1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人血小板反应蛋白1(THBS1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人血小板反应蛋白1(THBS1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人血小板反应蛋白1(THBS1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人血小板反应蛋白1(THBS1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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