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PLAU (基因名), Urokinase-type plasminogen activator (蛋白名), urok_human.

产品名称:

Human PLAU/ Urokinase-type plasminogen activator Recombinant Protein
尿激酶型纤溶酶原激活物

货号:

R0140h

商标:

EIAab^®

监管等级:

RUO

别名:

U-plasminogen activator

序列号:

P00749

来源:

E.coli

种属:

Human

标签:

His

序列:

21-177aa

预估分子量:

17.27 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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Human PLAU Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The PCR product of human PLAU gene was determined by 1% Agarose stained with EB.

Recombinant human PLAU protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 10q22.2 by HGNC 10q22.2 by Entrez Gene 10q22.2 by Ensembl

PLAU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Forms heterodimer with SERPINA5. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR. In complex with SERPINE1, interacts with PLAUR/uPAR (PubMed:15053742). Interacts with SORL1 and LRP1, either alone or in complex with SERPINE1; these interactions are abolished in the presence of LRPAP1/RAP (PubMed:15053742). The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORLA (PubMed:15053742).

功能:

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.77274

SMR:

P00749

STRING:

9606.ENSP00000361850

KEGG:

hsa:5328

MIM:

191840

Pfam:

PF00051

Uniprot:

P00749

相关产品

Mouse Plau ELISA Kit

Rat Plau ELISA Kit

Bovine PLAU ELISA Kit

Chicken PLAU ELISA Kit

Pig PLAU ELISA Kit

序列长度:

431

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

350:

400:

438:

SWGRGCALKD | KPGVYTRVSH | FLPWIR SHT | KEENGLAL

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene."

(PMID: 20007542)

[2].

"Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis."

(PMID: 17649957)

[3].

"A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease."

(PMID: 16825285)

[4].

"(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase."

(PMID: 10805774)

[5].

"Molecular cloning of cDNA coding for human preprourokinase."

(PMID: 2415429)

[6].

"Association of polymorphisms in the genes of the urokinase plasminogen activation system with susceptibility to and severity of non-small cell lung cancer."

(PMID: 20937265)

[7].

"No replication of genetic association between candidate polymorphisms and Alzheimer's disease."

(PMID: 19889475)

[8].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[9].

"Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes."

(PMID: 20452482)

[10].

"A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)."

(PMID: 20673868)

[1].

人尿激酶型纤溶酶原激活物(PLAU)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人尿激酶型纤溶酶原激活物(PLAU)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人尿激酶型纤溶酶原激活物(PLAU)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人尿激酶型纤溶酶原激活物(PLAU)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人尿激酶型纤溶酶原激活物(PLAU)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人尿激酶型纤溶酶原激活物(PLAU)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人尿激酶型纤溶酶原激活物(PLAU)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人尿激酶型纤溶酶原激活物(PLAU)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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