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VDAC1 (基因名), Voltage-dependent anion-selective channel protein 1 (蛋白名), vdac1_human.
产品名称:

Human VDAC1/ Voltage-dependent anion-selective channel protein 1 Recombinant Protein
电压依赖性阴离子选择性通道蛋白1

货号:

R12942h

商标:
EIAab®
监管等级:
别名:

Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC-1, VDAC

序列号:
P21796
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human VDAC1 Protein
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Human VDAC1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 5q31.1 by HGNC 5q31.1 by Entrez Gene 5q31.1 by Ensembl
VDAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
(Microbial infection) Interacts with influenza A virus PB1-F2 protein.


功能:
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).


亚细胞位置:
Mitochondrion outer membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Membrane raft Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1."

[2].
"Study of PTPC composition during apoptosis for identification of viral protein target."

[3].
"Gadolinium as an opener of the outwardly rectifying Cl(-) channel (ORCC). Is there relevance for cystic fibrosis therapy?"

[4].
"Subcellular localization of human voltage-dependent anion channel isoforms."

[5].
"Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms."

[6].
"Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel."

[7].
"Studies on human porin. IV. The primary structures of "Porin 31HM" purified from human skeletal muscle membranes and of "Porin 31HL" derived from human B lymphocyte membranes are identical."

[8].
"SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore."

[9].
"Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop."

[10].
"PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria."
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