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VHL (基因名), Von Hippel-Lindau disease tumor suppressor (蛋白名), vhl_canfa.
产品名称:

Dog VHL/ Von Hippel-Lindau disease tumor suppressor Recombinant Protein
HumanVonHippel-Lindaudiseasetumorsuppressor

货号:

R1894d

商标:
EIAab®
监管等级:
别名:

pVHL

序列号:
Q5Q9Z2
来源:
E.coli
种属:
Dog
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Dog VHL Protein
规格 & 价格: cart
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Dog VHL Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Part of a complex with Elongin BC complex and hydroxylated HIF1A. Interacts with CUL2. Part of multisubunit CBC(VHL) E3 ubiquitin ligase complexes with Elongin BC complex, CUL2 or CUL5 and RBX1. Interacts with HIF1AN. Part of a complex with HIF1A, HIF1AN and HDAC1 or HDAC2 or HDAC3. The C-terminus interacts with VBP1. Interacts with RNF139 and UBP33. Interacts with PHF17.


功能:
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.


亚细胞位置:
Cytoplasm Membrane Peripheral membrane protein Nucleus


该产品尚未在任何出版物中被引用。
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